Dietary supplement companies must adopt Current Good Manufacturing Practices (cGMPs) to ensure that procedures are in place in order to verify the identity, strength, purity, and composition of supplement ingredients. In addition to the Food and Drug Administration enforcement, independent regulatory agencies exist to verify cGMP compliance. Supplement companies must follow regulations governing claims, labeling, advertising, and packaging. The safety record of dietary supplements and resources to assess drug nutrient interactions are discussed. Understanding the regulatory and safety issues surrounding dietary supplements will help nutrition professionals have more confidence when recommending them as an adjunct to diet and lifestyle.