Nutraceuticals are becoming increasingly popular due to their growing awareness amidst the scientific sphere as a promising health-promoting agent. The opportunities for these products cover vast therapeutic areas such as inflammation, diabetes, cholesterol, osteoporosis, blood pressure, sleep disorders, digestion, cancer, and so on. Standardization of these compounds with respect to safety and efficacy is the prime requirement for which different countries have laid their regulatory norms that need to be clearly understood by the consumers and nutraceutical companies for making the judicious use of these norms. This chapter covers the opportunities and challenges faced by nutraceuticals and dietary supplements. This chapter promises to help the readers to familiarize with the regulatory framework of different countries namely the United States, the European Union, India, China, and Japan.