Commission removes the flavouring substance 4-methyl-2-phenylpent-2-enal (No FL 05.100) from the Union list
European Union
Jan 29, 2025
With the implementation of Regulation (EU) 2025/147 of 29 January 2025, the Commission amends Annex I of Regulation (EC) No 1334/2008 of the European Parliament and of the Council as regards the deletion of the flavouring substance 4-methyl-2-phenylpent-2-enal (FL No 05.100) from the Union list.
In its scientific opinion of 29 June 2022 (4), the Authority evaluated the submitted data and concluded that the representative substance of the FGE.216 revision 2 (FGE.216Rev2), 2-Phenylcrotonaldehyde (FL No 05.062), induced an aneugenicity mode of action. As the available in vivo micronucleus studies were inconclusive, an in vivo potential aneugenicity cannot be ruled out for any substance within FGE.216Rev2 and, therefore, for substance 4-Methyl-2-phenylpent-2-enal (FL No 05.100). Accordingly, the Authority indicated that further data were needed to complete the assessment.
Pending the submission of further data by interested food business operators, Commission Regulation (EU) 2024/238 (5) introduced restrictions on the use of 4-Methyl-2-phenylpent-2-enal (FL No 05.100).
As the concern for aneugenicity cannot be ruled out, 4-Methyl-2-phenylpent-2-enal (FL No 05.100) should be removed from the Union list of flavouring substances.
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